News

OHBM marzia

Marzia Scelsi has received a Merit Abstract Award for the 2017 OHBM Annual Meeting, taking place in Vancouver, Canada next June.

The paper by M. Scelsi et al., "Multimodal Imaging Disease Progression Scores as Quantitative Traits in GWAS of the ADNI Cohort", will be featured in an oral session on Neurological Disorders.

M. A. Scelsi, M. Lorenzi, J. M. Schott, S. Ourselin, A. Altmann, "Multimodal Imaging Disease Progression Scores as Quantitative Traits in GWAS of the ADNI Cohort"

Introduction

Quantitative trait genome-wide association studies (GWAS) in late-onset Alzheimer's disease (AD) using imaging biomarkers focused either on cross-sectional or on longitudinal phenotypes derived from a single imaging modality. However, since clinical and imaging biomarkers in AD are highly interrelated, association studies based on single biomarkers may miss genetic factors influencing their joint variation. In order to account for their joint variability, in this work we propose to use two well-established AD biomarkers to define a disease progression score (DPS), and to subsequently perform a GWAS using this DPS as a novel quantitative phenotype.