In collaboration with Centre of Advanced Biomedical Imaging (CABI, Lead by Professor Mark Lythgoe), our team develops imaging techniques to investigate the anatomical, structural and functional contributions of genes to human diseases and development using genetically modified mice. Our research effort in this large and multidisciplinary project is to provide image analysis capability for high-throughput high-resolution imaging (M. Modat, J. Cardoso, N. Powell, D. Ma).
Genetically modified mice are widely used in the preclinical studies of human brain diseases. Advanced computational imaging tools will be essential for efficiently extracting information from knockout mouse strains. Worldwide efforts to understand the role of genes in brain morphology demand efficient data acquisition and analysis framework to quantify the consequences of gene function in development and pathology. Large scale MRI phenotyping studies demand high-throughput acquisition and analysis of high-resolution 3D data. In particular, automatic, accurate quantitative methods for MR image analysis are essential for effective phenotyping. The aim for the phenotyping research in TIG is to build up fully automatic frameworks for high-throughput analysis for preclinical imaging, including quantitative morphometric analysis at voxel level and structural level.