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The Special Lecture, titled The Future of Image Guided Neurosurgery was delivered to a delegate group of clinical and non-clinical specialists and featured work on the EPI-Nav project. This symposium is the ninth in a series of focused high level symposia that address specific areas of epileptology, with a particular emphasis on the place of surgical treatments. This symposium focuses on the place of surgical treatment the treatment of epilepsies with acquired causes: stroke, trauma, tumour, infections and autoimmune conditions, with keynote lectures on the role of the blood–brain barrier and inflammatory pathways in the pathogenesis of epilepsies.