Medical image reconstruction, statistical modelling and analysis, neuroscience.
I am currently developing a software infrastructure for image reconstruction and analysis of PET and MR data acquired using a simultaneous whole body PET/MRI systems. This infrastructure is primarely dedicated to PET imaging in dementia.
The key strength of positron emission tomography (PET) is in providing high sensitivity measurement of the 4D radioactivity distribution in a 3D object over time after administration of a positron-emitting radiopharmaceutical (tracer). Depending on the tracer, a number of important physiological parameters may be estimated which are markers of functional, molecular and metabolic processes. On the other hand magnetic resonance imaging (MRI) provides high spatial and temporal resolution information unrivalled by any other imaging modalities with excellent soft-tissue contrast.
Combining the two imaging systems can add diagnostic and prognostic value in clinical research and practice. However, to take a full advantage of the combined PET/MR system, I facilitate the translation of newly developed algorithms using the latest GPU and CPU technology as to maximise the potential clinical impact of this project.
Rapid processing of PET list-mode data for efficient uncertainty estimation and data analysis. The software is based on the GPU/CUDA and wrapped in Python C-extensions. For more information see our recent articles in the journal of Physics in Medicine and Biology:
P J Markiewicz et al., (2016) Rapid processing of PET list-mode data for efficient uncertainty estimation and data analysis: http://dx.doi.org/10.1088/0031-9155/61/13/N322
P J Markiewicz et al., (2015) Assessment of bootstrap resampling performance for PET data: http://dx.doi.org/10.1088/0031-9155/60/1/279
The software can be downloaded here: https://cmiclab.cs.ucl.ac.uk/pmarkiew/NiftyPET
I obtained my PhD in 2007 from the University of Manchester, UK which focused on unified system modelling for whole body PET image reconstruction. Since then I conducted postdoctoral research at the University of Manchester (UK), McGill University (Canada) and Konstanz University (Germany) with emphasis on image reconstruction, statistical modelling, robust data analysis, pattern recognition and neuroscience.