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Translational Imaging Group
Centre for Medical Image Computing
Dept. Medical Physics and Biomedical Engineering
8.19 Malet Place Engineering Building

Gower Street
WC1E 6BT London
United Kingdom
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Miscellaneous Information

About Me

I studied Computer Science Engineering at Universitat de Girona (2004). I obtained post-graduates in Business Creation Based on Knowledge (2005), and in Education University (2006). I worked as a teacher in the Universitat de Girona and the Universitat Oberta de Catalunya. I'm one of the developers of e-learning project called ACME. I obtained the PhD degree from Universitat de Girona in 2012 investigating in visualization of diffusion tensor imaging. I joined CMIC, University College London, in May 2012 as a Research Associate of CMIC and Institute of Neurology.  My main research interests are in medical image registration and segmentation applied mainly to Multiple Sclerosis image analysis and computer-aided diagnosis.

 

Research Interests

Atrophy measurement, lesion detection and filling, computer-aided diagnosis, spinal cord imaging, sodium imaging, neurodegenerative diseases, DTI, e-learning.

 

Research

Multiple sclerosis is a complex disease. My research has been aimed on the development of new image processing algorithms that function as bio-markers suitable for clinical trials in Multiple Sclerosis diagnosis. Brain atrophy is being increasingly used as a marker of disease progression in many neurodegenerative diseases such as Multiple Sclerosis and Alzheimer's disease. I'm working to develop a new robust pipeline for brain atrophy measurement from serial MRI for multi-site imaging studies of Multiple Sclerosis. This pipeline mixes several CMIC and Institute of Neurology software tools as: Filling Lesions, for reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes;  BrainMAPS or STEPS, as multi-atlas propagation and segmentation technique for segmenting of the white matter and grey matter; NiftyReg, for the different registration steps; and finally, we used a generalised formulation of BSI, for measuring brain atrophy rates from Multiple Sclerosis. This new pipeline for brain atrophy measurement has been integrated at NiftK software platform. 

 

Most Recent Publications

 

2016

 

J. William L. BrownMatteo PardiniWallace J. BrownleeKryshani FernandoRebecca S. SamsonFerran PradosSebastien OurselinClaudia A. M. Gandini Wheeler-KingshottDavid H. MillerDeclan T. Chard. An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis. Brain Dec 2016, aww296; DOI: 10.1093/brain/aww296

Ferran PradosM. Jorge Cardoso, Marios C. Yiannakas, Luke R. Hoy, Elisa Tebaldi, Hugh Kearney, Martina D. Liechti, David H. Miller, Olga Ciccarelli, Claudia A. M. Gandini Wheeler-Kingshott & Sebastien OurselinFully automated grey and white matter spinal cord segmentation. Scientific Reports 6, Article number: 36151 (2016) doi:10.1038/srep36151

Marios C. Yiannakas, Francesco Grussu, Polymnia Louka, Ferran Prados, Rebecca S. Samson, Marco Battiston, Daniel R. Altmann, Sebastien Ourselin, David H. Miller, Claudia A. M. Gandini Wheeler-Kingshott. Reduced Field-of-View Diffusion-Weighted Imaging of the Lumbosacral Enlargement: A Pilot In Vivo Study of the Healthy Spinal Cord at 3T. October 2016. http://dx.doi.org/10.1371/journal.pone.0164890

Matteo Pardini, Carole H Sudre, Ferran Prados, Özgür Yaldizli, Varun Sethi, Nils Muhlert, Rebecca S Samson, Steven H van de Pavert, M Jorge Cardoso, Sebastien Ourselin, Claudia A M Gandini Wheeler-Kingshott, David H Miller, Declan T Chard. Relationship of grey and white matter abnormalities with distance from the surface of the brain in multiple sclerosis J Neurol Neurosurg Psychiatry (2016).

F. Prados, M. J. Cardoso, B. Kamber, O. Cicarelli, R. Kapoor, C. A. M. Wheeler-Kingshott, S. Ourselin. A multi-time-point modality-agnostic patch-based method for lesion filling in Multiple Sclerosis. NeuroImage (2016). Volume 139. 376-384. 

F. Prados, M. J. Cardoso, B. Kamber, N. Cawley, O. Cicarelli, C. A. M. Wheeler-Kingshott, S. Ourselin. Fully Automated Patch-Based Image Restoration: Application to Pathology Inpainting. BrainLes MICCAI workshop. MICCAI 2016 Athens.

F. Prados, M. Yiannakas, M. J. Cardoso, F. Grussu, F. De Angelis, D. Plantone, D. Miller, O. Ciccarelli, C. AM Wheeler-Kingshott, S. Ourselin (2016) Atrophy computation in the spinal cord using the Boundary Shift Integral. ISMRM 2016 - Singapore (Oral presentation).

F. Prados, M. J. Cardoso, M. Yiannakas, L. Hoy, E. Tebaldi, H. Kearney, M. Liechti, D. Miller, O. Ciccarelli, C. AM Wheeler-Kingshott, S. Ourselin (2016) Fully automated grey and white matter segmentation of the cervical cord in vivo. ISMRM 2016 - Singapore (Oral presentation).

F. Prados, B. S. Solanky, P. Alves Da Mota, M. J. Cardoso, W. J. Brownlee, F. Riemer, D. H. Miller, X. Golay, S. Ourselin, C. A.M. Wheeler-Kingshott (2016) Regional variation of total sodium concentration in the healthy human brain. ISMRM 2016 - Singapore (e-poster).

F. Prados, M. J. Cardoso, N. Burgos, C. AM Wheeler-Kingshott, S. Ourselin (2016) NiftyWeb: web based platform for image processing on the cloud. ISMRM 2016 - Singapore (traditional poster).

F. Prados, B. S. Solanky, P. Alves Da Mota, M. J. Cardoso, W. J. Brownlee, N. Cawley, D. H. Miller, X. Golay, S. Ourselin, C. A.M. Wheeler-Kingshott (2016) Automatic sodium maps reconstruction using PatchMatch algorithm for phantom detection. ISMRM 2016 - Singapore (e-poster).

F. Grussu, T. Schneider, F. Prados, C. Tur, S. Ourselin, H. Zhang, D. C. Alexander, C. A.M. Wheeler-Kingshott (2016) Axon diameter distribution influences diffusion-derived axonal density estimation in the human spinal cord: in silico and in vivo evidence. ISMRM 2016 - Singapore (Traditional -poster).

M. Battiston, F. Grussu, J. Fairney, F. Prados, S. Ourselin, M. Cercignani, C. A.M. Wheeler-Kingshott, R. S. Samson (2016) Reduced Field-of-View Diffusion-Weighted Imaging of the Lumbosacral Enlargement: A Pilot In Vivo study of the healthy spinal cord using a clinical 3T MR system. ISMRM 2016 - Singapore (Oral presentation).

M. C. Yiannakas, P. Louka, F. Grussu, F. Prados, R. S. Samson, M. Battiston, S. Ourselin, D. H. Miller, C. A. M. Wheeler-Kingshott (2016) In vivo quantitative Magnetisation Transfer in the cervical spinal cord using reduced Field-of-View imaging: a feasibility study. ISMRM 2016 - Singapore (e-poster).

F. Prados, M. Yiannakas, M. J. Cardoso, F. Grussu, F. De Angelis, D. Plantone, D. Miller, O. Ciccarelli, C. AM Wheeler-Kingshott, S. Ourselin (2016) Computing spinal cord atrophy using the Boundary Shift Integral: a more powerful outcome measure for clinical trials? ECTRIMS 2016 - London (Poster presentation).

A. Eshaghi, F. Prados, W. Brownlee, C. Tur, S.H. van de Pavert, N. Cawley, D.R. Altmann, D. Chard, N. De Stefano, M. Laura Stromillo, M. Battaglini, S. Ruggieri, C. Gasperini, M. Filippi, M.A. Rocca, A. Rovira, J. Sastre-Garriga, H. Vrenken, M. Steenwijk, C. Leurs, S. Ourselin, C.A.G. Wheeler-Kingshott, D.H. Miller, F. Barkhof, A.J. Thompson, D.C. Alexander, O. Ciccarelli, on behalf of the MAGNIMS study group. Imaging signature of multiple sclerosis phenotypes in grey matter. ECTRIMS 2016 - London. (Oral presentation)

W.J. Brownlee, P. Alves Da Mota, F. Prados, B. Solanky, F. Riemer, M.J. Cardoso, S. Ourselin, X. Golay, C.A. Gandini Wheeler-Kingshott, D.H. Miller, O. Ciccarelli. Increased cortical and deep grey matter sodium concentration is associated with physical and cognitive disability in relapse-onset multiple sclerosis. ECTRIMS 2016 - London. (Oral presentation)

S. Collorone, N. Cawley, F. Prados, C. Tur, F. Grussu, B. Kanber, S. Ourselin, C.A.M. Gandini Wheeler-Kingshott, D.H. Milller, A. Thompson, A. Toosy, O. Ciccarelli. Neurite Orientation Dispersion and Density Imaging (NODDI) reflects early microstructural brain tissue changes in clinically isolated syndrome (CIS). ECTRIMS 2016 - London. (Poster)

S.H. van de Pavert, M. Pardini, A. Eshaghi, F. Prados, Ö. Yaldizli, V. Sethi, S. Ourselin, C.A. Gandini Wheeler-Kingshott, D.H. Miller, O. Ciccarelli, D.T. Chard. Spatial and temporal characteristics of magnetisation transfer ratio changes in different corticothalamic systems in multiple sclerosis. ECTRIMS 2016 - London. (Poster)

C. Tur, A. Eshaghi, TM. Jenkins, D.R. Altmann, F. Prados, T. Charalambous, J.D. Clayden, S. Ourselin, C.A.M. Gandini Wheeler-Kingshott, D.H. Miller, A.J. Thompson, O. Ciccarelli, AT. Toosy. Structural cortical networks in optic neuritis (early CIS). ECTRIMS 2016 - London. (Poster)

C. Tur, A. Eshaghi, Z. Khaleeli, D.R. Altmann, F. Prados, T. Charalambous, J.D. Clayden, S. Ourselin, C.A.M. Gandini Wheeler-Kingshott, DH. Miller, A.J. Thompson, A.T. Toosy, O. Ciccarelli. Longitudinal changes in structural cortical networks in early PPMS. ECTRIMS 2016 - London. (Poster)

M. Pardini, C.H. Sudre, F. Prados, Ö. Yaldizli, V. Sethi, N. Muhlert, R.S. Samson, S.H.P. van de Pavert, M.J. Cardoso, S. Ourselin, C.A. Gandini Wheeler-Kingshott, D.H. Miller, D.T. Chard. The relationship of grey and white matter abnormalities with distance from the surface of the brain in multiple sclerosis. ECTRIMS 2016 - London. (Poster)

F. Tona, N. Cawley, F. Grussu, F. Prados, S. Ourselin, L. Kipp, C.A. Gandini Wheeler-Kingshott, O. Ciccarelli. Neurite orientation dispersion and density imaging (NODDI) of the spinal cord in relapsing remitting multiple sclerosis. ECTRIMS 2016 - London. (Poster)

B. Kanber, F. Prados, N. Cawley, A. Eshaghi, S. Collorone, C.A.M. Wheeler-Kingshott, F. Barkhof, O. Ciccarelli, S. Ourselin. An integrated imaging informatics software platform to improve the analysis of clinical trials and research data in MS. ECTRIMS 2016 - London. (Poster)

R.S. Samson, W.J. Brownlee, M.J. Cardoso, W.J. Brown, M. Pardini, F. Prados, S. Ourselin, C.A.M. Gandini Wheeler-Kingshott, D.H. Miller, D.T. Chard. Outer and inner cortical MTR abnormalities in clinically isolated syndromes. ECTRIMS 2016 - London. (Poster) 

R. Cortese, L. Magnollay, F. De Angelis, F. Prados, F. Grussu, C. Tur, M. Yiannakas, I.L. Simone, D.R. Altmann, D. Miller, S. Ourselin, C.A. M. Gandini Wheeler-Kingshott, F. Barkhof, O. Ciccarelli. No differences in spinal cord DTI abnormalities between neuromyelitis optica spectrum disorder and multiple sclerosis. ECTRIMS 2016 - London. (Poster)

N. Cawley, B.S. Solanky, F. Prados, S. Collorone, B. Kanber, S. Ourselin, C.A.M. Gandini Wheeler-Kingshott, D.H. Miller, A.J. Thompson, A. Toosy, O. Ciccarelli. Increased total sodium concentration in asymptomatic T2 lesions in clinically isolated syndrome. ECTRIMS 2016 - London. (Poster) 

T. Charalambous, C. Tur, J.D. Clayden, F. Prados, S.H.P. van Pavert, D. Chard, D.H. Miller, S. Ourselin, C.A.M. Gandini Wheeler-Kingshott, A.J. Thompson, A.T. Toosy. Changes in diffusion-based structural brain network in relapsing-remitting multiple sclerosis. ECTRIMS 2016 - London. (Poster) 

L. Kipp, N. Cawley, F. Prados, T. Schneider, S. Ourselin, CAM Gandini Wheeler-Kingshott, DH Miller, A. Thompson, O Ciccarelli. Neurite Orientation Dispersion and Density Imaging (NODDI) in RRMS. Annual Meeting of American Academy of Neurology 2016 - Vancouver (Canada).

R. Cortese, L. Magnollay, F. De Angelis, C. Tur, F. Prados, F. Grussu, S. Ourselin, M. Yiannakas, D. Miller, T. Yousry, O. Cicarelli. No Differences in Spinal Cord White and Grey Matter Diffusion Abnormalities between Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis. Annual Meeting of American Academy of Neurology 2016 - Vancouver (Canada).

R. Cortese, L. Magnollay, F. De Angelis, C. Tur, F. Prados, S. Ourselin, M. Yiannakas, D. Miller, T. Yousry, O. Cicarelli. The Central Vein Sign on SWI at 3T MRI Differentiates Multiple Sclerosis from Neuromyelitis Optica. Annual Meeting of American Academy of Neurology 2016 - Vancouver (Canada).

S. Collorone, N. Cawley, F. Prados, S. Ourselin, C. Tur, F. Grussu, CAM Gandini Wheeler-Kingshott, DH Miller, A. Thompson, A. Toosy, O Ciccarelli. Neurite Orientation Dispersion and Density Imaging (NODDI) at the Onset of Clinically Isolated Syndrome (CIS): New Insights in the Early Microstructural Brain Tissue Changes. Annual Meeting of American Academy of Neurology 2016 - Vancouver (Canada).

N.Cawley, B.S.Solanky, F.Prados, S. Collorone, S. Ourselin, CAM Gandini Wheeler – Kingshott, D. H Miller, A.J. Thompson, A.Toosy, O. Ciccarelli. Brain tissue sodium concentration in clinically isolated syndrome. Annual Meeting of American Academy of Neurology 2016 - Vancouver (Canada).

WJ Brownlee, P Alves Da Mota, F Prados, T Schneider, MJ Cardoso, DR Altmann, S Ourselin, CAM Gandini Wheeler-Kingshott, O Ciccarelli, DH Miller. Neurite orientation dispersion and density imaging (NODDI) measures are associated with long-term disability and secondary progression in relapse-onset MS. Annual Meeting of American Academy of Neurology 2016 - Vancouver (Canada).

 

 

2015

 

F. Prados, M. J. Cardoso, N. Cawley, O. Ciccarelli, C. A. M. Wheeler-Kingshott, S. Ourselin. Multi-Contrast PatchMatch Algorithm for Multiple Sclerosis Lesion Detection. ISBI 2015 -Longitudinal MS Lesion Segmentation Challenge. New York (USA)

R. Cortese, L. Magnollay, F. De Angelis, C. Tur, F. Prados, S. Ourselin, M. Yiannakas, D. Miller, T. Yousry, O. Ciccarelli. Perivenular white matter lesions on SWI at 3-T MRI as a potential biomarker to differentiate multiple sclerosis from neuromyelitis optica. ECTRIMS 2015 - Barcelona (Catalonia)

L. Kipp, N. Cawley, F. Prados, T. Schneider, S. Ourselin, C.A. Wheeler-Kingshott, D.H. Miller, A.J. Thompson, O. Ciccarelli. Neurite orientation dispersion and density imaging (NODDI) in RRMS. ECTRIMS 2015 - Barcelona (Catalonia) 

P. Alves Da Mota, F. Prados, W. J. Brownlee, M. J. Cardoso, M. Pardini, N. Toussaint. D. T. Chard, S. Ourselin, D. H. Miller, C. A. M. Wheeler-Kingshott. Comparison of segmentation techniques to measure tissue-specific atrophy in Multiple Sclerosis. ISMRM 2015 - Toronto (Canada).

N.M. Powell, D. Ma, F. Prados, M. Modat, J. Cardoso, H.E. Holmes, O. Ismail, N. Colgan, M. O'Neill, E.C. Collins, M.F. Lythgoe, S. Ourselin. The Boundary Shift Integral sensitively measures longitudinal whole-brain atrophy in a mouse model of tauopathy. ISMRM 2015 - Toronto (Canada).

P. Alves Da Mota, M. C. Yiannakas, F. Prados, M. J. Cardoso, D. Pailing, F. Riemer, D. Toezer, S. Ourselin, D. H. Miller, X. Golay, C. A. M. Wheeler-Kingshott, B. S. Solanky. Relationship of Sodium concentration and T2 relaxation in Multiple Sclerosis. ISMRM 2015 - Toronto (Canada).

B. S. Solanky, P. Alves Da Mota, F. Prados, T.Schneider, F. Riemer, W. J. Brownlee, F. Grussu, M. J. Cardoso, S. Ourselin, H. Zang, D. H. Miller, X. Golay, C. A. M. Wheeler-Kingshott. Combined Sodium NODDI: Towards quantitative in vivo intracellular and intraneurite sodium measures at 3T. ISMRM 2015 - Toronto (Canada).

W. J. Brownlee, P. Alves Da Mota, F. Prados, J. K. Swanton, K. A. Miszkiel, D. R. Altmann, S. Ourselin, C. A. M. Wheeler-Kingshott, O. Ciccarelli, D. H. Miller. Factors associated with spinal cord atrophy in the first five years after a clinically isolated syndrome. Annual Meeting of American Academy of Neurology 2015 - Washington (USA). 

W. J. Brownlee, P. Alves Da Mota, F. Prados, J. K. Swanton, K. A. Miszkiel, D. R. Altmann, S. Ourselin, C. A. M. Wheeler-Kingshott, O. Ciccarelli, D. H. Miller. Early spinal cord MRI abnormalities are associated with MS-related disability five years after a clinically isolated syndrome. Annual Meeting of American Academy of Neurology 2015 - Washington (USA).

 

2014

 

F. Prados, M. J. Cardoso, C. A. M. Wheeler-Kingshott, S. Ourselin. A modality agnostic patch-based technique for lesion filling in Multiple Sclerosis. MICCAI 2014 

F. Prados, M. J. Cardoso, K. K. Leung, D. M. Cash, M. Modat, N. C. Fox, C. A. M. Wheeler-Kingshott, S. Ourselin. Measuring brain atrophy with a generalised formulation of the boundary shift integral. Neurobiology of Aging 2014

F. Prados, M. J. Cardoso, D. M. Cash, M. Modat, C. A. M. Wheeler-Kingshott, S. Ourselin. Robust and Fully-Automated Atrophy Measure for Multiple Sclerosis Disease. ISMRM 2014 - Milan (Italy). 

 

A list of previous publications can be found here.