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Research Interests: brain MRI, brain regsitration, brain segmentation, brain development, diffusion tensor imaging, spectral matching, preterm infants, newborn, fetus

             

             Current position: Research Scientist at Philips GmbH Innovative Technologies, Research Laboratories, Hamburg, Germany,

             Department of Digital Imaging

 

About me: I completed my Bachelor degree in Physics and Earth and Space Sciences at Jacobs University Bremen in Germany. I wrote my Physics Bachelor thesis in cooperation with Fraunhofer MEVIS on a project dealing with compartment modelling of the liver and deconvolution techniques based on perfusion and hepatic extraction. I joined the DTP programme at UCL in 2012 as an MRes student and I started my PhD with TIG in 2013. Submitted PhD Thesis in October 2016 on "Longitudinal Analysis of Extreme Prematurity: a Neuroimage Investigation of Early Brain Development"

 

Research at TIG: I am working in the field of Neonatal Brain Imaging. My research is part of the Sparks project and consists of investigating the longitudinal folding of the cortex in babies born extremely preterm (around 25 weeks of gestation) using their structural and diffusion MR scans at preterm and term equivalent ages (30 and 40 weeks estimated gestational age, respectively). To quantify the longitudinal changes over the preterm period, I used a longitudinal correspondence found with spectral matching techniques  (surface spectral matching, tensor spectral matching), which I adapted and developed for this particular type of subjects. Knowing the neurological differences and risks that can occur is useful to predict impairment and how this can be avoided by early treatment.

 

What I liked about TIG: Motivational environment, great co-workers - always eager to help! 

 

 

Whole brain matching of longitudinal surfaces in an extremely preterm infant, scanned twice, using Joint-Spectral Matching. The matching is colour coded anterior-posterior.

 

Publications:

 

2016

 

Journal Papers: 

  • Eliza Orasanu,Andrew Melbourne, M. Jorge Cardoso, Herve Lombaert, Giles Kendall, Nicola Robertson, Neil Marlow, and Sebastien Ourselin. Cortical folding of the preterm brain: a longitudinal analysis of extremely-preterm born neonates using spectral matching. Brain and Behavior, 2016. DOI: http://onlinelibrary.wiley.com/doi/10.1002/brb3.488/full
  • Andrew Melbourne, Zach Eaton-Rosen, Eliza Orasanu,David Price, Alan Bainbridge, M. Jorge Cardoso, Giles Kendall, Nicola Robertson, Neil Marlow, and Sebastien Ourselin. Longitudinal development in the preterm thalamus and posterior white matter; MRI correlations between Diffusion Weighted Imaging and T2 relaxometry. Human Brain Mapping, 2016.
  • Nicholas Dingwall, Alan Chalk, Teresa I. Martin, Catherine J. Scott, Carla Semedo, Quan Le, Eliza Orasanu, Jorge M. Cardoso, Andrew Melbourne, Neil Marlow, and Sebastien Ourselin. T2 relaxometry in the extremely-preterm brain at adolescence. MRI, 2016. DOI: http://dx.doi.org/10.1016/j.mri.2015.12.020

 

Conference Papers:

  •  Eliza Orasanu, Pierre-Louis Bazin, Andrew Melbourne, Marco Lorenzi, Herve Lombaert, N. J. Robertson, G. S. Kendall, Nikolaus Weiskopf, N. Marlow, and S. Ourselin. Longitudinal Analysis of the Preterm Cortex Using Multi-Modal Spectral Matching. In MICCAI. Lecture Notes in Computer Science, 2016.
  • Zach Eaton-Rosen, M. Jorge Cardoso, Andrew Melbourne, Eliza Orasanu, Alan Bainbridge,  G. S. Kendall, N. J. Robertson, N. Marlow, and S. Ourselin. Fitting parametric models of diffusion MRI in regions of partial volume. In SPIE Medical Imaging, 2016.

 

Conference Abstracts: 

  • Eliza Orasanu, Andrew Melbourne, Zach Eaton-Rosen, David Atkinson, Joshua Lawan, Joanne Beckmann, Neil Marlow, and Sebastien Ourselin. Local shape analysis of the thalamus in extremely preterm born young adults. Accepted for Oral Presentation at ISMRM, 2016.
  • Eliza Orasanu, Andrew Melbourne, Zach-Eaton Rosen, David Atkinson, Alexandra Saborowska, Joanne Beckmann, Neil Marlow, and Sebastien Ourselin. Cortical folding patterns in extremely preterm born young adults. Accepted for Electronic Poster at ISMRM, 2016.
  • Eliza Orasanu, Andrew Melbourne, Marc Modat, Marco Lorenzi, Herve Lombaert, Zach Eaton-Rosen, Nicola Robertson, Giles Kendall, Neil Marlow, and Sebastien Ourselin. Mapping longitudinal white matter changes in extremely preterm born infants. Accepted for Oral Presentation at ISMRM, 2016.
  • Zach Eaton-Rosen, Andrew Melbourne, Eliza Orasanu, Joanne Beckmann, Nicola Stevens, David Atkinson, Neil Marlow, and Sebastien Ourselin. White matter alterations in young adults born extremely preterm: a microstructural point of view. Accepted for ISMRM, 2016.
  • Andrew Melbourne, Eliza Orasanu, Zach Eaton-Rosen, Manuel J Cardoso, Joanne Beckmann, Lorna Smith, David Atkinson, Neil Marlow, and Sebastien Ourselin. Analysis of brain volume in a 19 year-old extremely- preterm born cohort. Accepted for ISMRM, 2016. 
  • Andrew Melbourne, Zach Eaton-Rosen, Eliza Orasanu, Joanne Beckmann, Alexandra Saborowska, David Atkinson, Neil Marlow, and Sebastien Ourselin. Perfusion and diffusion in the extremely preterm young adult thalamus. Accepted for ISMRM, 2016.
  • Andrew Melbourne, Eliza Orasanu, Zach Eaton-Rosen, Joanne Beckmann, Alexandra Saborowska, David Atkinson, Neil Marlow, and Sebastien Ourselin. Characterizing microstructure and shape of the extremely preterm 19 year-old corpus callosum. Accepted for ISMRM, 2016.
  • E. Orasanu, A. Melbourne, H. Lombaert, M. J. Cardoso, G. S. Kendall, N. J. Robertson, N. Marlow, and S. Ourselin. Cortical folding of the preterm brain: a longitudinal analysis using spectral matching. Oral Presentation at Mind, Brain and Body Symposium (Berlin, Germany), 2016

 

2015

 

Journal Papers:

  • E. Orasanu, A. Melbourne, M.J. Cardoso, M. Modat, A.M. Taylor, S. Thayyil, and S. Ourselin, Brain volume estimation from post-mortem newborn and fetal MRI. Neuroimage: Clinical. 6: 438-444, 2015. DOI: http://dx.doi.org/10.1016%2Fj.nicl.2014.10.007
  • Z. Eaton-Rosen, A. Melbourne, E. Orasanu, M.J. Cardoso, A. Bainbridge, G.S. Kendall, N.J. Robertson, N. Marlow, and S. Ourselin. Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI. Neuroimage, 2015, 111, 580-589.

 

 

Conference Papers:

  • E. Orasanu, A. Melbourne, M. Lorenzi, M. Modat, H. Lombaert, Z. Eaton-Rosen, G. S. Kendall, N. J. Robertson, N. Marlow, and S. Ourselin. Tensor Spectral Matching of Diffusion Weighted Images. Accepted for Workshop on Spectral Analysis in Medical Imaging (SAMI), MICCAI, 2015. http://hdl.handle.net/10380/3528
  • E. Orasanu, A. Melbourne, H. Lombaert, M. J. Cardoso, S. Johnsen, G. S. Kendall, N. J. Robertson, N. Marlow, and S. Ourselin. Pre-frontal cortical folding of the preterm brain: a longitudinal analysis of preterm-born neonates. In Workshop on Spatiotemporal Image Analysis for Longitudinal and Time-Series Image Data (STIA), MICCAI 2014, LNCS 8682, pp. 3-12, 2015, DOI: 10.1007/978-3-319-14905-9_1 http://link.springer.com/chapter/10.1007%2F978-3-319-14905-9_1

 

2014

 

Conference Abstracts:

  • E. Orasanu, A. Melbourne, M.J. Cardoso, M. Modat, A.M. Taylor, S. Thayyil, and S. Ourselin, Fully automated estimation of brain volumes in post-mortem newborn and stillborn infants. In ISMRM 2014, 1517
  • E. Orasanu, A. Melbourne, M.J. Cardoso, M. Modat, A.M. Taylor, S. Thayyil, and S. Ourselin, Average probabilistic brain atlases for post-mortem newborn and stillborn populations and application to tissue segmentation. In ISMRM 2014, 2001.
  • Z. Eaton-Rosen, A. Melbourne, E. Orasanu, A. Bainbridge, G.S.Kendall, N.J. Robertson, N. Marlow and S. Ourselin. Cortical maturation in the preterm period revealed using a multi-component diffusion-weighted MR model. In ISMRM 2014, 80.

 

Conference Papers:

  • Z. Eaton-Rosen, A. Melbourne, E. Orasanu, M. Modat, A. Bainbridge, M. J. Cardoso, G. S. Kendall, N. J. Robertson, N. Marlow, and S. Ourselin. Longitudinal measurement of the developing thalamus in the very-preterm brain using multi-modal MRI. In MICCAI. Lecture Notes in Computer Science, 2014.